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The Benefits of Fish Collagen as a Biomedical Material May 18, 2023

Fish collagen is a promising new biomedical material that offers several advantages over collagen derived from terrestrial mammals. One of its primary benefits is its good biological safety. Fish collagen is similar in structure and function to mammalian collagen, but has lower immunogenicity and better safety. This means it poses a lower risk of zoonotic virus transmission and is safer for clinical use. In vivo and in vitro biocompatibility studies have shown that fish collagen gel extract is sterile and non-toxic, with no evidence of sensitization, chromosomal aberration, intradermal reaction, acute systemic toxicity, pyrogen reaction, or hemolytic reaction.


Another advantage of fish collagen is that it can circumvent religious barriers in certain regions and groups. Due to religious beliefs, pig-derived collagen medical products cannot be used clinically in Islamic countries and regions. Fish collagen, on the other hand, does not have these religious restrictions and can benefit patient groups in related regions and countries more smoothly.


Fish collagen also has the advantage of being abundant in source. China is a major producer of aquatic products and generates a large amount of fish processing by-products every year. Approximately 40% of these by-products are fish skins, which are often considered waste and discarded. This not only ignores their potential value but can also cause environmental pollution. The application and development of fish collagen in the medical field provides a more economical and safer source of new collagen materials while also increasing the added value of fish skin, a by-product of aquatic product processing. This reduces pressure on environmental protection and aligns with the national goal of building a marine power strategic orientation.


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