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Dissolution Method of Hydroxypropyl Methylcellulose (HPMC) Dec 03, 2021

HPMC Classification and Functions

Hydroxypropyl methyl cellulose, also known as hydroxypropyl methyl cellulose and cellulose hydroxypropyl methyl ether, is made using highly pure cotton cellulose as raw material, which has been specially etherified under certain conditions.
Hot water dissolution method: Since HPMC does not dissolve in hot water, initially HPMC can be dispersed evenly in hot water and subsequently dissolved quickly when cooled. Two typical methods are described as follows.
1. Place the required amount of hot water in a container and heat to approximately 70°C. The HPMC floats on the surface of the water at first and then gradually forms a slurry which is cooled with stirring.
2. Prepare a hot water slurry by adding 1/3 or 2/3 of the required amount of water to the vessel and heating to 70°C. Disperse the HPMC as in 1, then add the remaining amount of cold water to the hot water slurry and cool the mixture after stirring.
Powder Mixing Method: The HPMC powder is mixed with a large amount of other powdered substances and mixed thoroughly with a mixer, after which water is added to dissolve it. Then the HPMC can be dissolved at this point without clumping and coalescing, because each tiny little corner, with only a little HPMC powder, will dissolve immediately when it meets water. --Putty powder and mortar manufacturers use exactly this method. ( Hydroxypropyl methyl cellulose (HPMC) is used as a thickening agent and water retention agent in putty powder mortars.)

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